Methanol → HCID 18475331、化合物

HRID 2187347ノート

反応式

HRID 2187347 の反応式
C([C:3]([C:12]#[N:13])([CH:7]([CH:9]1[CH2:11][CH2:10]1)[CH3:8])[C:4]([OH:6])=[O:5])C.CO.[OH-].[Na+]>O1CCCC1>[C:12]([CH:3]([CH:7]([CH:9]1[CH2:10][CH2:11]1)[CH3:8])[C:4]([OH:6])=[O:5])#[N:13]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium Hydroxide2 回HCID 18475322HCID 18475322、化合物

生成物 1

HCID 18475331HCID 18475331、化合物収率 86.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

39.8 g (0.22 mol) of ethyl 2-cyano-3-cyclopropylbutanoic acid were refluxed for 4 hours in a mixture of in each case 150 ml of methanol, tetrahydrofuran and 2 N sodium hydroxide solution. For working-up, 200 ml of 2 N sodium hydroxide solution were added and the mixture was extracted repeatedly with diethyl ether. The aqueous phase was subsequently acidified by adding hydrochloric acid and also extracted with ether. After this organic phase had been dried and concentrated, 29 g (yield 86%) of 2-cyano-3-cyclopropylbutanoic acid were obtained.

後処理

  1. extractionthe mixture was extracted repeatedly with diethyl ether
  2. additionby adding hydrochloric acid
  3. extractionalso extracted with ether
  4. customAfter this organic phase had been dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-bd3409541e604d0c95ce869bf35f17f1
出典データセット
uspto-grants-2002_06
特許番号
US06410486B1

反応ノート

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