Methyl iodide → N,N-diethyl 2-chloro-6-methylbenzamide

HRID 2188113

反応式

HRID 2188113 の反応式
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH3:15]I>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([CH3:15])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]

参加物

3

反応物 2

HCID 6328Methyl iodideHCID 825662-Chloro-N,N-diethylbenzamide

生成物 1

HCID 18630133N,N-diethyl 2-chloro-6-methylbenzamide収率 92%

実験手順

The compound from example e (1.0 eq) and MeI (3.0 eq) were combined according to Method A. The crude product was purified by HPLC with 1:4 EtOAc/hexanes to give 5.2 g of N,N-diethyl 2-chloro-6-methylbenzamide as a yellow solid, a 92% yield. m.p. 48°-49° C.

後処理

  1. customThe crude product was purified by HPLC with 1:4 EtOAc/hexanes

出典と根拠

ORDレコード
ord-6e4686cee83448fdaf5bb2bce7a792cc
出典データセット
uspto-grants-2002_06
特許番号
US06410558B1

関連ノート

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