3,4-Dichlorobenzotrifluoride → [2-Chloro-5-(trifluoromethyl)phenyl]hydrazine

HRID 2188256ノート

反応式

HRID 2188256 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[Cl:8].O.[NH2:14][NH2:15]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[NH:14][NH2:15].[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([F:12])([F:11])[F:10])=[CH:3][C:2]=1[NH:14][NH2:15]

参加物

5

反応物 2

HCID 94813,4-DichlorobenzotrifluorideHCID 24654Hydrazine hydrate (1:1)

生成物 2

HCID 2060249[2-Chloro-5-(trifluoromethyl)phenyl]hydrazineHCID 2736687(2-Chloro-4-(trifluoromethyl)phenyl)hydrazine

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
150 °C

実験手順

A mixture of 3,4-dichlorobenzotrifluoride (48 g), hydrazine hydrate (65 g) and pyridine (240 g) was stirred and heated at 150° C. for 6 hours in an autoclave at a pressure of 4 bar. The cooled mixture was quenched with sodium hydroxide solution and the organic layer evaporated in vacuo. The residue was dissolved in diethyl ether, washed (water) and the ether evaporated to give 2-chloro-4-trifluoromethylphenylhydrazine and 2-chloro-5-trifluoromethylphenylhydrazine as a 95/5 mixture (36 g),

後処理

  1. customThe cooled mixture was quenched with sodium hydroxide solution
  2. customthe organic layer evaporated in vacuo
  3. dissolutionThe residue was dissolved in diethyl ether
  4. washwashed (water)
  5. customthe ether evaporated

出典と根拠

ORDレコード
ord-63687c2795ab47eba8505e66b61fc6b6
出典データセット
uspto-grants-2002_06
特許番号
US06410737B1

反応ノート

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