Sodium Hydroxide → 3-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxyacetic acid

HRID 2189084ノート

反応式

HRID 2189084 の反応式
C[O:2][C:3](=[O:34])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]2[C:14]3[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[C:20]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[O:19][C:15]=3[N:16]=[CH:17][N:18]=2)[CH:7]=1.[OH-].[Na+]>C1COCC1>[C:22]1([C:21]2[C:14]3[C:13]([NH:12][C:8]4[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=4)[O:5][CH2:4][C:3]([OH:34])=[O:2])=[N:18][CH:17]=[N:16][C:15]=3[O:19][C:20]=2[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 582802413-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxyacetic acid methyl ester

生成物 1

HCID 582801903-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxyacetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

Dissolve 50 mg (0.111 mmol) of 3-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxyacetic acid methyl ester in 2 ml of THF, add 0.33 ml of 1N sodium hydroxide solution at RT and stir at 50° C. for 1 h. Cool to RT and remove the THF under reduced pressure. Add water to the residue and then, with ice cooling, 1N hydrochloric acid. Filter off the precipitated solid, wash repeatedly with water and dry under reduced pressure. 39.4 mg (81.3% of theory) of the target compound are obtained as a white solid.

後処理

  1. temperatureCool to RT
  2. customremove the THF under reduced pressure
  3. filtrationFilter off the precipitated solid
  4. washwash repeatedly with water
  5. customdry under reduced pressure
  6. custom39.4 mg (81.3% of theory) of the target compound are obtained as a white solid

出典と根拠

ORDレコード
ord-35dcfe3dd4e546489a9bdbaa5236f22c
出典データセット
uspto-grants-2012_12
特許番号
US08324222B2

反応ノート

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