Sodium Carbonate → 4-Oxo-2-nonenal

HRID 2191167ノート

反応式

HRID 2191167 の反応式
[CH2:1]([C:6]1[O:7][CH:8]=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH3:5].ClC1C=CC=C(C(OO)=[O:19])C=1.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[O:19]=[C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])/[CH:10]=[CH:9]/[CH:8]=[O:7]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 196022-PentylfuranHCID 70297m-Chloroperbenzoic acid

生成物 1

HCID 64455374-Oxo-2-nonenal収率 73%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.0 g (14.47 mmol) of 2-pentylfuran was dissolved in 60 ml of dichloromethane, and 3.84 g (14.47 mmol) of 65% m-chloroperbenzoic acid was added dropwise thereto with stirring under ice-cooling, followed by stirring for 1 hour at the same temperature. To the reaction solution was added saturated aqueous sodium carbonate and the mixture was extracted with dichloromethane. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and was then concentrated under reduced pressure to give 1.62 g of the title compound as a yellow oil (yield: 73%).

後処理

  1. temperaturecooling
  2. stirringby stirring for 1 hour at the same temperature
  3. extractionthe mixture was extracted with dichloromethane
  4. washThe organic layer was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationwas then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-14feb5106d584d0ea75c76b6171c5a7c
出典データセット
uspto-grants-2012_12
特許番号
USRE043858E1

反応ノート

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