Potassium Phosphate, Tribasic → (1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone

HRID 2191947

反応式

HRID 2191947 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([C:12]1[CH:17]=[CH:16][C:15]([O:18][C:19]2[C:24](Cl)=[N:23][CH:22]=[CH:21][N:20]=2)=[CH:14][CH:13]=1)=[O:11].P([O-])([O-])([O-])=O.[K+].[K+].[K+].[F:34][C:35]([F:46])([F:45])[C:36]1[CH:41]=[C:40](B(O)O)[CH:39]=[CH:38][N:37]=1>C(COC)OC>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([C:12]1[CH:17]=[CH:16][C:15]([O:18][C:19]2[C:24]([C:40]3[CH:39]=[CH:38][N:37]=[C:36]([C:35]([F:46])([F:45])[F:34])[CH:41]=3)=[N:23][CH:22]=[CH:21][N:20]=2)=[CH:14][CH:13]=1)=[O:11]

参加物

5

反応物 3

HCID 62657Potassium Phosphate, TribasicHCID 451588802-(Trifluoromethyl)pyridine-4-boronic acidHCID 46207940HCID 46207940、化合物

生成物 1

HCID 46207696(1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

反応条件

温度
80 °C

実験手順

A mixture of (1H-benzo[d]imidazol-2-yl)(4-(3-chloropyrazin-2-yloxy)phenyl)methanone (300 mg, 0.855 mmol), potassium phosphate (545 mg, 2.57 mmol), 2-(trifluoromethyl)pyridin-4-ylboronic acid (490 mg, 2.57 mmol), and Bis-[4-(di-tert-butylphosphino)-N,N-dimethylbenzenamine]palladium dichloride (121 mg, 0.171 mmol) in dimethoxyethane was heated to 80° C. Following complete reaction, the mixture was cooled to room temperature which caused a solid to precipitate which was collected by filtration and dried to give (1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone. MS (ESI, pos. ion) m/z: 461.0 (M+1). IC50 (uM) +++++.

後処理

  1. customreaction
  2. temperaturethe mixture was cooled to room temperature which
  3. customto precipitate which
  4. filtrationwas collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-2a77f3befe9441f5bb0e9669a9b1d366
出典データセット
uspto-grants-2012_12
特許番号
US08329700B2

関連ノート

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