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Diisopropylethylamine → N-(3-(3-(4-methoxyphenyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-indol-6-yl)phenyl)-3-morpholino-5-(trifluoromethyl)benzamide

HRID 2192277
ノート
印刷プレビュー

反応式

HRID 2192277 の反応式
CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[O:25]1[CH2:30][CH2:29][N:28]([C:31]2[CH:32]=[C:33]([CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=2)[C:34]([O-:36])=O)[CH2:27][CH2:26]1.[NH2:44][C:45]1[CH:46]=[C:47]([C:51]2[CH:59]=[C:58]3[C:54]([C:55]([C:68]4[CH:73]=[CH:72][C:71]([O:74][CH3:75])=[CH:70][CH:69]=4)=[CH:56][N:57]3[C:60]3[N:65]=[CH:64][N:63]=[C:62]([NH:66][CH3:67])[CH:61]=3)=[CH:53][CH:52]=2)[CH:48]=[CH:49][CH:50]=1.CCN(C(C)C)C(C)C.C(=O)(O)[O-].[Na+]>C1COCC1>[CH3:75][O:74][C:71]1[CH:70]=[CH:69][C:68]([C:55]2[C:54]3[C:58](=[CH:59][C:51]([C:47]4[CH:46]=[C:45]([NH:44][C:34](=[O:36])[C:33]5[CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=[C:31]([N:28]6[CH2:27][CH2:26][O:25][CH2:30][CH2:29]6)[CH:32]=5)[CH:50]=[CH:49][CH:48]=4)=[CH:52][CH:53]=3)[N:57]([C:60]3[CH:61]=[C:62]([NH:66][CH3:67])[N:63]=[CH:64][N:65]=3)[CH:56]=2)=[CH:73][CH:72]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 509920026-(6-(3-aminophenyl)-3-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amineHCID 866513803-Morpholino-5-(trifluoromethyl)benzoate

生成物 1

HCID 50992088
N-(3-(3-(4-methoxyphenyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-indol-6-yl)phenyl)-3-morpholino-5-(trifluoromethyl)benzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

HATU (100 mg, 0.260 mmol) was added to a mixture solution of 3-morpholino-5-(trifluoromethyl)benzoate (54 mg, 0.195 mmol), 6-(6-(3-aminophenyl)-3-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amine (55 mg, 0.130 mmol) and DIPEA (45 μL, 0.26 mmol) in THF (2 mL) at room temperature. 12 hours later, the mixture was added to saturated sodium bicarbonate aqueous solution and then extracted with methylene chloride. The collected organic layer was washed with brine and then concentrated under reduced pressure by drying with anhydrous magnesium sulfate. The residue was purified by chromatography (preparative HPLC). The target compound was obtained as yellow solid.

後処理

  1. extractionextracted with methylene chloride
  2. washThe collected organic layer was washed with brine
  3. concentrationconcentrated under reduced pressure
  4. dry with materialby drying with anhydrous magnesium sulfate
  5. customThe residue was purified by chromatography (preparative HPLC)
  6. customThe target compound was obtained as yellow solid

出典と根拠

ORDレコード
ord-54cb49254a1c4ccab06db7da91fc5c19
出典データセット
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08329708B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート