Sodium carbonate (85 mg) and PdCl2(dppf)2 (50 mg) were added sequentially to a suspension of 1-bromo-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline (D40; 180 mg) and 3-(dihydroxyboranyl)benzoic acid (Aldrich; 99 mg) in 1,2-dimethoxyethane (DME; 2 ml), ethanol (1 ml) and water (1 ml). The resulting suspension was heated to 80° C. and stirred for overnight. The solvent was evaporated in vacuo and the residue was purified by MDAP to give the title compound (20 mg). δH (DMSO-d6, 400 MHz): 1.37 (6H, d), 4.90 (1H, m), 7.48 (1H, d), 7.73 (1H, t), 7.86 (1H, t), 7.95 (1H, dd), 8.19 (5H, m), 8.60 (1H, dd), 8.78 (2H, m), 13.17 (1H, br s).
