Tetrahydrofuran → 1-(4-Fluorophenyl)-4-(hydroxymethyl)pyrrolidin-2-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14](OC)=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[BH4-].[Na+].C1COCC1>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH:10]([CH2:14][OH:15])[CH2:11][C:12]2=[O:13])=[CH:4][CH:3]=1参加物
5
実験手順
A 500 mL round-bottomed flask was charged with methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate 52 (7.50 g, 31.6 mmol), sodium borohydride (1.32 g, 34.8 mmol), and 100 mL of THF. After being heated to reflux, 15 mL of MeOH was slowly added. After 1 h at reflux, the reaction was concentrated, 100 mL of water was added, and the mixture was extracted with DCM. The combined extracts were dried and concentrated to give 1-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidin-2-one 53.
後処理
- temperatureAfter being heated
- temperatureto reflux
- temperatureAfter 1 h at reflux
- concentrationthe reaction was concentrated
- addition100 mL of water was added
- extractionthe mixture was extracted with DCM
- customThe combined extracts were dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-04ad25007de045b3a5ebda4da637cc98
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08334317B2
反応ノート
読み込み中…