Sodium Hydroxide → 2-Amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline

HRID 2195695ノート

反応式

HRID 2195695 の反応式
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](O)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:23])[CH3:22])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1.P(Cl)(Cl)([Cl:26])=O.[OH-].[Na+]>C(#N)C>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([Cl:26])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:23])[CH3:22])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 178473878HCID 178473878、化合物

生成物 1

HCID 670236312-Amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The mixture of 1.7 g 2-amino-3-cyano-4-hydroxy-6-(4-acetylpiperazin-1-yl)quinoline, 50 ml acetonitrile and 3.4 ml phosphoryl chloride is heated at reflux temperature for 4 hours. The cooled reaction mixture is poured onto 30 g ice, the pH of the mixture is set to 8 with 10% sodium hydroxide solution and the resulting precipitate is filtered off. After drying 1.5 g of the title compound is obtained (MH+: 330).

後処理

  1. temperatureis heated
  2. temperatureat reflux temperature for 4 hours
  3. customThe cooled reaction mixture
  4. filtrationthe resulting precipitate is filtered off
  5. dry with materialAfter drying 1.5 g of the title compound
  6. customis obtained (MH+: 330)

出典と根拠

ORDレコード
ord-ab6b82694678450b85ddf3844f42e428
出典データセット
uspto-grants-2012_12
特許番号
US08338411B2

反応ノート

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