Hydrochloric Acid → Sodium Chloride
反応式
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([O:12][CH3:13])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+:15].[ClH:16].C1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([O:12][CH3:13])[N:9]=1.[Cl-:16].[Na+:15]参加物
7
実験手順
To a solution of 200 mg (1.092 mmol) 3-amino-5-methoxy-pyrazine-2-carboxylic acid methyl ester in 4 ml THF was added 1.20 ml (1.20 mmol) 1N sodium hydroxide and the mixture was stirred at room temperature for 29 h. To the mixture were added 1.09 ml (1.09 mmol) 1N HCl after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as colorless solid. The mixture was used for coupling reactions without further purification.
後処理
- additionwas added
- customthe solvents were evaporated
出典と根拠
- ORDレコード
- ord-7eabecf3706b4db8b0d722023bc69538
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08338413B1
反応ノート
読み込み中…