Sodium borohydride → 9-Hydroxymethyl-9,10-dihydro-9,10-methanoanthracene

HRID 2198646

反応式

HRID 2198646 の反応式
[CH:1]([C:3]12[CH2:17][CH:10]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=31)[C:9]1[C:4]2=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:2].[BH4-].[Na+]>CO.O>[OH:2][CH2:1][C:3]12[CH2:17][CH:10]([C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=31)[C:11]1[C:16]2=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 124041419,10-Methanoanthracene-9(10H)-carbaldehyde

生成物 1

HCID 130690829-Hydroxymethyl-9,10-dihydro-9,10-methanoanthracene

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 9-formyl-9,10-dihydro-9,10-methanoanthracene (200 mg) and sodium borohydride (60 mg) in methanol (5 ml) was stirred at room temperature for 30 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-hydroxymethyl-9,10-dihydro-9,10-methanoanthracene. M.P. 165°-166° C.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-b4b5c81661214b2ab17ab7850509a70e
出典データセット
uspto-grants-1982_11
特許番号
US04358620

関連ノート

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