Tetrahydrofuran → Methyl 5-[5-(2,2'-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-hydroxybenzoate

HRID 219925ノート

反応式

HRID 219925 の反応式
[NH2:1][C:2](=[N:14][OH:15])[C:3]1[CH:4]=[CH:5][C:6]([OH:13])=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9].CCN([CH:22]([CH3:24])[CH3:23])C(C)C.[CH2:25]1[CH2:29]O[CH2:27][CH2:26]1>O>[CH3:27][C:26]1[CH:2]=[C:3]([C:12]2[O:15][N:14]=[C:2]([C:3]3[CH:4]=[CH:5][C:6]([OH:13])=[C:7]([CH:12]=3)[C:8]([O:10][CH3:11])=[O:9])[N:1]=2)[CH:4]=[CH:5][C:25]=1[C:29]1[CH:8]=[CH:7][CH:6]=[CH:24][C:22]=1[CH3:23]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 136346389HCID 136346389、化合物

生成物 1

HCID 136346390Methyl 5-[5-(2,2'-dimethylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl]-2-hydroxybenzoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
150 °C

実験手順

Under Argon atmosphere, Intermediate 3 (147.08 mg; 0.65 mmol) was stirred in anhydrous DCM (5 mL). Oxalyl chloride (57.75 μL; 0.68 mmol) was added followed by DMF (0.50 μL; 0.01 mmol). The reaction mixture was stirred 3 hours at RT. Solvents were evaporated to give 2,2′-dimethylbiphenyl-4-carbonyl chloride as a yellow oil. The latter was dissolved in anhydrous THF (3 mL), Intermediate 46 (136.62 mg; 0.65 mmol) and DIEA (221.08 μL; 1.30 mmol) were added under argon. The mixture was heated in the microwave at 150° C. for 15 min. The reaction mixture was diluted in water and extracted with EtOAc, the organic phase was then washed with NH4Cl, NaHCO3 and NaCl sat. solution. The organic layer was then dried over magnesium sulfate, filtered and concentrated, the crude product was purified by flash chromatography (c-hex/EtOAc: 9.5/0.5), affording the title compound. LC/MS (Method A): 398.9 (M−H)−, 400.8 (M+H)+. HPLC (Method A) Rt 6.37 min (Purity: 98.8%).

後処理

  1. extractionextracted with EtOAc
  2. washthe organic phase was then washed with NH4Cl, NaHCO3 and NaCl sat. solution
  3. dry with materialThe organic layer was then dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customthe crude product was purified by flash chromatography (c-hex/EtOAc: 9.5/0.5)

出典と根拠

ORDレコード
ord-e6a6dae620714768b8cfbf3834af9d9d
出典データセット
uspto-grants-2012_06
特許番号
US08202865B2

反応ノート

読み込み中…