4-(4-Nitrophenyl)pyridine → 4-(Pyridin-4-yl)aniline

HRID 2200452

反応式

HRID 2200452 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[N:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

参加物

4

反応物 1

HCID 2592194-(4-Nitrophenyl)pyridine

生成物 1

HCID 15126544-(Pyridin-4-yl)aniline収率 90.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-(4-nitrophenyl)pyridine (274 mg, 1.37 mmol) and Pd—C (10%, 80 mg) in MeOH (10 mL) was hydrogenated under balloon H2 for 20 h. The mixture was then filtered through celite. The filtrate was concentrated in vacuo to give 4-(pyridin-4-yl)aniline as a solid (211 mg).

後処理

  1. filtrationThe mixture was then filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-7a25cde2b5b54a6f9767270dfdca7728
出典データセット
uspto-grants-2016_06
特許番号
US09359308B2

関連ノート

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