Thionyl Chloride → 5-(Chloromethyl)-2-methylpyrimidine

HRID 2200560

反応式

HRID 2200560 の反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][N:3]=1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][C:5]1[CH:4]=[N:3][C:2]([CH3:1])=[N:7][CH:6]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 14686706(2-Methylpyrimidin-5-yl)methanol

生成物 1

HCID 146866995-(Chloromethyl)-2-methylpyrimidine

実験手順

A solution of (2-methylpyrimidin-5-yl)methanol (95 mg, 0.77 mmol) in thionyl chloride (1 mL) was stirred at room temperature for 1 h. The mixture was concentrated to dryness and used without purification. LCMS MH+ 143.

後処理

  1. concentrationThe mixture was concentrated to dryness
  2. customused without purification

出典と根拠

ORDレコード
ord-2a2b5487c26648388f8b0c144ea6dbcf
出典データセット
uspto-grants-2016_06
特許番号
US09359359B2

関連ノート

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