Lithium Bromide → HCID 86715161、化合物
反応式
[N:1]1([C:7]([O:9][CH2:10]Cl)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br-:12].[Li+]>C(#N)C>[N:1]1([C:7]([O:9][CH2:10][Br:12])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 90 °C
実験手順
Chloromethyl morpholine-4-carboxylate [6316] (0.3 g, 1.67 mmol, 1.0 eq) and lithium bromide (0.72 g, 8.3 mmol, 5.0 eq) was taken in acetonitrile (10 ml). The reaction was refluxed at 90° C. for 30 h. Reaction progress was monitored by TLC/1H NMR. The reaction was filtered off and filtrate was evaporated to dryness under reduced pressure to yield light brown gel, bromomethyl morpholine-4-carboxylate [6327](0.30 g, 80%)
後処理
- customReaction progress
- filtrationThe reaction was filtered off
- customfiltrate was evaporated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-fb25a01e9294454ba56cec7b8fcabcfc
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359376B2
反応ノート
読み込み中…