Iodine → HCID 178505763、化合物
反応式
[Zn:1].II.[Br:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.C[Si](Cl)(C)C>O1CCCC1>[Br-:4].[F:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][Zn+:1])=[CH:7][CH:8]=1参加物
6
実験手順
To a stirred mixture of Zn metal (18.5 g, 289.06 mmol, 1.09 equiv), I2 (500 mg, 1.97 mmol, 0.01 equiv) and 1-(bromomethyl)-4-fluorobenzene (5 g, 0.10 equiv) in anhydrous tetrahydrofuran (50 mL) maintained under nitrogen at room temperature was added dropwise a solution of 1-(bromomethyl)-4-fluorobenzene (45 g, 211.6 mmol, 0.90 equiv) in tetrahydrofuran (200 mL). TMSCl (500 mg, 4.60 mmol, 0.02 equiv) was then added dropwise to the reaction. The resulting mixture was refluxed for 10 h. The solution was cooled to 0° C. and used in the next step immediately.
後処理
- temperatureThe resulting mixture was refluxed for 10 h
- temperatureThe solution was cooled to 0° C.
出典と根拠
- ORDレコード
- ord-82d8d67e34174504a05b01a8d455fba3
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365527B2
反応ノート
読み込み中…