Trifluoroacetic acid → HCID 178483309、化合物
反応式
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C:11]1[NH:15][C:14]2[C:16]([O:20][CH3:21])=[CH:17][CH:18]=[CH:19][C:13]=2[N:12]=1)C)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:21][O:20][C:16]1[C:14]2[NH:15][C:11]([CH2:10][CH2:9][NH:7][CH3:6])=[N:12][C:13]=2[CH:19]=[CH:18][CH:17]=1参加物
4
実験手順
A solution of 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL DCM was treated with 0.39 mL of TFA and stirred overnight at rt. The reaction mixture was concentrated in vacuo, redissolved in DCM and treated with diluted NaOH. After separation of the 2 phases the water phase was lyophilized to yield 380 mg of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amine as beige solid.
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- dissolutionredissolved in DCM
- additiontreated with diluted NaOH
- customAfter separation of the 2 phases the water phase
出典と根拠
- ORDレコード
- ord-9d1d1ccde96d430e95a9e09857093f57
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202885B2
反応ノート
読み込み中…