N-bromobutanimide → 2-Ethoxycarbonylimino-3-(3-trifluoromethylpheny)-5-bromothiazoline

HRID 22029

反応式

HRID 22029 の反応式
[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH2:10][CH2:9][S:8]1)=[O:5])[CH3:2].[Br:22]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:21])[F:19])[CH:13]=2)[CH:10]=[C:9]([Br:22])[S:8]1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 542258332-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

生成物 1

HCID 540969932-Ethoxycarbonylimino-3-(3-trifluoromethylpheny)-5-bromothiazoline収率 45.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine (1.6 g) and N-bromosuccinimide (2 g) in chloroform (50 ml) was refluxed for 10 hours. After cooling, the reaction mixture was washed with an aqueous sodium sulfite solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.9 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylpheny)-5-bromothiazoline (Compound No. 30).

後処理

  1. temperatureAfter cooling
  2. washthe reaction mixture was washed with an aqueous sodium sulfite solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-e9219addc6ce432f8c50f7527d001711
出典データセット
uspto-grants-1995_06
特許番号
US05426188

関連ノート

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