Hydrazine hydrate (1:1) → 4-chloro-1H-pyrazolo[4,3-c]pyridine
反応式
[Cl:1][C:2]1[C:7]([CH:8]=O)=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>COCCOC>[Cl:1][C:2]1[C:7]2[CH:8]=[N:12][NH:13][C:6]=2[CH:5]=[CH:4][N:3]=1参加物
4
反応条件
- 温度
- 75 °C
実験手順
To a solution of 2,4-dichloropyridine-3-carbaldehyde (7.0 g) in DME (70 mL) was added hydrazine monohydrate (8.0 g) at room temperature. The reaction mixture was stirred overnight at 75° C., and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (4.0 g).
後処理
- concentrationconcentrated under reduced pressure
- customThe residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether)
出典と根拠
- ORDレコード
- ord-7f68ff6a687a4beabe077440bd05a565
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09371320B2
反応ノート
読み込み中…