Iodine → HCID 178478341、化合物
反応式
[Cl:1][C:2]1[C:7]2[CH:8]=[N:9][NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[OH-].[K+].[I:13]I.S([O-])([O-])(=O)=S.[Na+].[Na+]>COCCOC>[Cl:1][C:2]1[C:7]2[C:8]([I:13])=[N:9][NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1参加物
6
反応条件
- 温度
- 75 °C
実験手順
To a mixture of 4-chloro-1H-pyrazolo[4,3-c]pyridine (4.0 g) and potassium hydroxide (4.4 g) in DME (50 mL) was added iodine (13.3 g) at room temperature. The reaction mixture was stirred at 75° C. for 4 hr. The reaction mixture was added to aqueous sodium thiosulfate solution, and the mixture was left stand overnight, and the resulting solid was collected by filtration to give the title compound (6.3 g).
後処理
- waitthe mixture was left stand overnight
- filtrationthe resulting solid was collected by filtration
出典と根拠
- ORDレコード
- ord-5e0d89dc4c6544d79511c505d2dcf26b
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09371320B2
反応ノート
読み込み中…