Sodium Bicarbonate → Methyl 3-{[(2R,6R)-1-benzyl-2,6-dimethylpiperidin-4-yl]amino}-5-fluoro-2-methylbenzoate

反応式

[NH2:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH2:14]([N:21]1[C@@H:26]([CH3:27])[CH2:25][C:24](=O)[CH2:23][C@H:22]1[CH3:29])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C([O-])(O)=O.[Na+]>C1COCC1.C(O)(C(F)(F)F)=O>[CH2:14]([N:21]1[C@H:26]([CH3:27])[CH2:25][CH:24]([NH:1][C:2]2[C:3]([CH3:13])=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=2)[C:5]([O:7][CH3:8])=[O:6])[CH2:23][C@H:22]1[CH3:29])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1