Methyl iodide → 5-Bromo-1,2-dimethyl-3-nitrobenzene
反応式
[Br:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=O.C(=O)([O-])[O-].[Na+].[Na+].CI>CN(C=O)C>[CH3:7][C:6]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]=1[CH3:11]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To stirred solution of 5-bromo-2-methyl-3-nitrobenzoic acid, prepared analogously to above, (287 g, 1103 mmol) in DMF (150 mL), sodium carbonate (468 g, 4415 mmol) and methyl iodide (626.6 g, 4415 mmol) were added. Resulting mixture was heated at 60° C. for 8 h. On completion, solid was remove by filtration, and the residue washed with diethyl ether (5 times). The combined organic layers were dried, concentrated under reduced pressure to give methyl 5-bromo-2-methyl-3-nitrobenzene (302 g, 99%).
後処理
- customResulting mixture
- customOn completion, solid was remove by filtration
- washthe residue washed with diethyl ether (5 times)
- customThe combined organic layers were dried
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-9104854ee5da4a6eb6955f0e39a2cc11
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09376422B2
反応ノート
読み込み中…