4-Coumaric acid → 2-Propenoic acid, 3-phenyl-

HRID 22094

反応式

HRID 22094 の反応式
O[C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>CS(C)=O>[C:8]([OH:10])(=[O:9])[CH:7]=[CH:6][C:5]1[CH:4]=[CH:3][CH:2]=[CH:12][CH:11]=1

参加物

3

反応物 1

HCID 3224-Coumaric acid

生成物 1

HCID 87842-Propenoic acid, 3-phenyl-

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
90 °C

実験手順

2.8 g of p-hydroxy cinnamic acid was dissolved in 3 ml of DMSO, and 10 mg of sodium hydride of which the oil was washed by hexane was added. The mixture was stirred and heated to 90° C. under a flow of N2 gas. 5.0 g of glycidol was added gradually, heating and agitation were carried out for 1.5 hours, neutralized by adding hydrochloric acid and then the adduct of cinnamic acid and glycerin was obtained.

後処理

  1. wash10 mg of sodium hydride of which the oil was washed by hexane
  2. additionwas added
  3. addition5.0 g of glycidol was added gradually
  4. temperatureheating
  5. additionby adding hydrochloric acid

出典と根拠

ORDレコード
ord-2231e991bda54208932c1c846850f007
出典データセット
uspto-grants-1995_06
特許番号
US05426210

関連ノート

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