Iodobenzene → tert-butyl N-[2-(1-phenylpiperidin-4-yl)ethyl]carbamate
反応式
CC(C)(C)OC(=O)NCCC1CCNCC1.Ic1ccccc1>CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.COCCOC.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Pd]>CC(C)(C)OC(=O)NCCC1CCN(c2ccccc2)CC1参加物
7
反応物 2
生成物 1
試薬・触媒・溶媒 4
反応条件
- 温度
- 100 °C
実験手順
To a solution of tert-butyl 2-(piperidin-4-yl)ethylcarbamate (0.342 g, 1.5 mmol) in anhydrous DME were added iodobenzene (0.444 g, 2.18 mmol), bis(tri-t- butylphosphine)palladium(0) (0.077 g, 0.15 mmol) and potassium phosphate (0.245 mL, 3.00 mmol). The reaction was heated to 100°C overnight. This reaction did not work.
出典と根拠
- ORDレコード
- ord-cc832050b1854993a53bbd02bde64312
- 出典データセット
- 750 AstraZeneca ELN dataset
- 元リンク
- 出典を表示
反応ノート
読み込み中…