2-Bromododecanoic acid → 2-chlorododecanoic Acid

HRID 2210836

反応式

HRID 2210836 の反応式
Br[CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4].[Cl-:16].[Ca+2].[Cl-]>C(#N)C.[Cl-].C([N+](CC)(CC)CC)C>[Cl:16][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4]

参加物

5

反応物 2

HCID 669802-Bromododecanoic acidHCID 5284359Calcium Chloride

生成物 1

HCID 43873702-chlorododecanoic Acid

試薬・触媒・溶媒 2

HCID 5946Tetraethylammonium Chloride触媒HCID 6342Acetonitrile溶媒

実験手順

To 2-bromododecanoic acid (1 g), after having been dissolved in acetonitrile (50 ml ), were added calcium chloride (2 g) and tetraethylammonium chloride (1 g), and the mixture was heated under reflux for 4 hours. The reaction mixture was filtered, concentrated and distributed into ethyl acetate and water, and the ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated to give 2-chlorododecanoic acid.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated
  5. dry with materialthe ethyl acetate layer was dried over anhydrous sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-1166962bf9cc4f59a854ba6f25ac7e21
出典データセット
uspto-grants-1995_10
特許番号
US05461036

関連ノート

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