Dimethyl Disulfide → tert-butyl 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methylsulfanyl-1H-imidazole-4-carboxylate

To a cooled (−20° C.) and magnetically stirred solution of tert-butyl 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-1H-imidazole-4-carboxylate (10.59 g, 25.0 mmol), in anhydrous THF (100 ml) was added LDA (15.0 ml, 2 M solution in heptane/THF, 30.0 mmol) and the resulting mixture was stirred for 1 hour under N2. A solution of (CH3S)2 (2.7 ml, 30.0 mmol) in THF (20 ml) was added and the resulting solution was successively stirred at −40° C. for 1 h, allowed to attain room temperature and stirred for another 16 h. A saturated aqueous NH4Cl solution (250 ml) was added and the resulting solution was extracted twice with ethyl acetate (EtOAc). The combined organic layers were washed with water, dried over MgSO4, filtered and concentrated to give tert-butyl 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-methylsulfanyl-1H-imidazole-4-carboxylate in 90% yield as an oil which slowly solidified; 1H-NMR (200 MHz, CDCl3) δ 1.66 (s, 9H), 2.28 (s, 3H), 7.05 (br d, J˜8 Hz, 2H), 7.25 (dd, J=8 and 2 Hz, 1H), 7.28 (d, J=2 Hz, 1H), 7.32–7.41 (m, 3H).

1. stirringthe resulting solution was successively stirred at −40° C. for 1 h
2. customto attain room temperature
3. stirringstirred for another 16 h
4. extractionthe resulting solution was extracted twice with ethyl acetate (EtOAc)
5. washThe combined organic layers were washed with water
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated

ORDレコード

ord-3524d4aaf9e140ab813e8a6e98ce74b1

出典データセット

uspto-grants-2006_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07109216B2