Water → HCID 21948877、化合物

HRID 2215439ノート

反応式

HRID 2215439 の反応式
[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N:16]=[CH:17][C:18]([C:33]([F:36])([F:35])[F:34])([OH:32])[CH2:19][C:20]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[O:30][CH3:31])([CH3:22])[CH3:21])[N:7]=1)(=[O:3])[CH3:2].[BH4-].[Na+].O>CO.O1CCCC1>[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH:16][CH2:17][C:18]([C:33]([F:34])([F:35])[F:36])([OH:32])[CH2:19][C:20]([C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[O:30][CH3:31])([CH3:22])[CH3:21])[N:7]=1)(=[O:3])[CH3:2]

参加物

6

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 21948882HCID 21948882、化合物

生成物 1

HCID 21948877HCID 21948877、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution that consists of 170 mg (0.34 mmol) of 1-(2-(acetoxymethyl)quinolin-5-ylimino)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)pentan-2-ol in 1.5 ml of methanol and 0.8 ml of tetrahydrofuran is mixed with 53 mg (1.38 mmol) of sodium borohydride. After 3 hours at room temperature, the reaction is halted by adding water. It is extracted with ethyl acetate, the combined organic phases are washed with saturated sodium chloride solution and dried on sodium sulfate. After removal of the solvent and chromatography on silica gel with hexane-ethyl acetate (0–100%), 94 mg (55% of theory) of the product is obtained.

後処理

  1. extractionIt is extracted with ethyl acetate
  2. washthe combined organic phases are washed with saturated sodium chloride solution
  3. customdried on sodium sulfate
  4. customAfter removal of the solvent and chromatography on silica gel with hexane-ethyl acetate (0–100%), 94 mg (55% of theory) of the product
  5. customis obtained

出典と根拠

ORDレコード
ord-e1c2d6c73c5b4fcd9c563c0c5711f78e
出典データセット
uspto-grants-2006_09
特許番号
US07109212B2

反応ノート

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