Sodium borohydride → (4-[1,2,3]Triazol-2-yl-phenyl)-methanol
反応式
[N:1]1[N:2]([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][CH:7]=2)[N:3]=[CH:4][CH:5]=1.[BH4-].[Na+]>C1COCC1.CO>[N:1]1[N:2]([C:6]2[CH:7]=[CH:8][C:9]([CH2:10][OH:11])=[CH:12][CH:13]=2)[N:3]=[CH:4][CH:5]=1参加物
5
実験手順
To a solution of 42.26 g (244 mmol) of 4-[1,2,3]-triazol-2-yl-benzaldehyde in 140 ml of THF and 420 ml of MeOH, 9.23 g (244 mmol) of NaBH4 are added portionwise at 0–5° C. and the mixture is stirred for 30 min. at the same temperature. The reaction is quenched with sat. NH4Cl at 0–5° C. and the mixture is extracted with AcOEt. The combined extracts are washed with brine, dried over MgSO4 and concentrated under reduced pressure to give the title compound as a colorless solid.
後処理
- customThe reaction is quenched with sat. NH4Cl at 0–5° C.
- extractionthe mixture is extracted with AcOEt
- washThe combined extracts are washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-936aa10a07a04a97a4a814eeef6d73b9
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07112611B2
反応ノート
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