反応式
[Li+].[CH3:2][CH:3]([N-]C(C)C)C.[CH:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11][CH2:10]1.ICC.Cl>C1COCC1>[CH2:2]([C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11][CH2:10]1)[CH3:3]参加物
6
実験手順
To a solution of LDA (100 ml; 2.0 M THF solution) in THF (100 ml) was added dropwise over a period of 20 minutes under cooling with ice, a solution of cyclobutane carboxylic acid (10 g, 0.1 mol) in THF (15 ml) and the mixture was stirred at RT for 2 h. To the mixture iodoethane (15.6 g, 0.1 mol) was added dropwise and the mixture was stirred at RT overnight. To the reaction mixture was added 2N HCl and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine to afford the title compound as a light yellow oil (22.4 g), which was used in the next step without purification.
後処理
- temperatureunder cooling with ice
- extractionthe mixture was extracted with ethyl acetate
- washThe organic layer was washed with water and brine
出典と根拠
- ORDレコード
- ord-a086e21e98ef4d3b9faf30d0048b3e70
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07410991B2
関連ノート
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