Sodium Hydroxide → 1-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

HRID 2218315ノート

反応式

HRID 2218315 の反応式
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][N:11]=[C:12]2[CH:15]2[CH2:17][CH2:16]2)=[C:7]([O:18][CH3:19])[CH:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.CO>[CH:15]1([C:12]2[C:13]3[C:8](=[C:7]([O:18][CH3:19])[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:14]=3)[CH:9]=[CH:10][N:11]=2)[CH2:16][CH2:17]1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 57440910Methyl 1-cyclopropyl-5-methoxyisoquinoline-7-carboxylate

生成物 1

HCID 574408921-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

1-Cyclopropyl-5-methoxy-isoquinoline-7-carboxylic acid methyl ester (4.87 g, 18.9 mmol) was dissolved in THF (50 ml) and MeOH (50 ml), and 5N NaOH aq. (18.9 ml) was added thereto. After stirred at 60° C. for 2 h, the mixture was concentrated in vacuo. The residue was triturated with H2O and 5N HCl aq. (18.9 ml) and the insoluble solid was collected through filtration to obtain the intended compound as a colorless solid.

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was triturated with H2O and 5N HCl aq. (18.9 ml)
  3. filtrationthe insoluble solid was collected through filtration

出典と根拠

ORDレコード
ord-922d78239cae478aafc6930a9df9cfeb
出典データセット
uspto-grants-2008_08
特許番号
US07410976B2

反応ノート

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