Water → ((4-Cyclohexylphenoxy)methyl)oxirane

HRID 221948

反応式

HRID 221948 の反応式
[CH2:1]1[O:3][C@H:2]1[CH2:4]Cl.[CH:6]1([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>C(#N)C>[CH:6]1([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:4][CH:2]3[CH2:1][O:3]3)=[CH:16][CH:17]=2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

参加物

6

反応物 4

HCID 962WaterHCID 10796Cesium carbonateHCID 143274-CyclohexylphenolHCID 2734062(-)-Epichlorohydrin

生成物 1

HCID 5743581((4-Cyclohexylphenoxy)methyl)oxirane

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a mixture of R-epichlorohydrin (9.8 g, 106 mmol) and 4-cyclohexylphenol (3.73 g, 21.2 mmol) in acetonitrile (40 ml) was added cesium carbonate (6.9 g, 21.2 mmol). The mixture was heated at reflux for 3 hours. The reaction mixture was cooled, poured into water (100 mL) and extracted twice with EtOAc. The organic phases were combined and washed with water, brine, dried (Na2SO4), concentrated and dried under high vacuum overnight to give the title compound.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 3 hours
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted twice with EtOAc
  5. washwashed with water, brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated
  8. customdried under high vacuum overnight

出典と根拠

ORDレコード
ord-d3037173a1b8480bbbcf4512227dd842
出典データセット
uspto-grants-2012_06
特許番号
US08207181B2

関連ノート

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