Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

HRID 2219847

反応式

[CH3:1][CH:2]([N:4]1[C:12](/[CH:13]=[CH:14]/[CH:15]([OH:23])[CH2:16][CH:17]([OH:22])[CH2:18][C:19]([OH:21])=[O:20])=[C:11]([C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2)[CH3:3].[OH-].[Na+:32]>O>[CH3:3][CH:2]([N:4]1[C:12](/[CH:13]=[CH:14]/[CH:15]([OH:23])[CH2:16][CH:17]([OH:22])[CH2:18][C:19]([O-:21])=[O:20])=[C:11]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2)[CH3:1].[Na+:32]

参加物

実験手順

Fluvastatin (3.52 g) was stirred in a solution of H2O (9.9 ml) and NaOH (s) (0.32 g) at room temperature to obtain a mud-like suspension. The suspension was stirred at room temperature over night. The product was filtered under nitrogen flow, washed with H2O (2×3 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 3.36 g (65.8%) of fluvastatin sodium Form LIV.

後処理

customto obtain a mud-like suspension
filtrationThe product was filtered under nitrogen flow
washwashed with H2O (2×3 ml)
customdried at 50° C. in a vacuum oven for 24 h

出典と根拠

ORDレコード: ord-b2941f60a7d041208d5d0052c94cd723
出典データセット: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07414140B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート