Sodium Hydroxide → 3-(4-Bromophenyl)propan-1-amine
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([NH2:12])=O)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][NH2:12])=[CH:6][CH:7]=1参加物
5
実験手順
To a solution of 3-(4-bromophenyl)propanamide (1.59 g) in tetrahydrofuran (24 ml) was added lithium aluminum hydride (370 mg) and the mixture was refluxed for 1.5 hours under nitrogen atmosphere. After cooling to room temperature, the reaction mixture was poured into 1N aqueous sodium hydroxide solution (100 ml). The mixture was extracted with ethyl acetate and the organic layer was washed with water and brine and dried over magnesium sulfate. Filtration followed by evaporation under reduced pressure gave 3-(4-bromophenyl)-1-propanamine (1.55 g) as a yellow oil.
後処理
- temperaturethe mixture was refluxed for 1.5 hours under nitrogen atmosphere
- extractionThe mixture was extracted with ethyl acetate
- washthe organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- filtrationFiltration
- customfollowed by evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-82dcca47e4514eafa7e49ce9c52c622a
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07417060B2
反応ノート
読み込み中…