Ethanol → (4-([2-(2-Furyl)-1,3-oxazol-4-yl]methoxy)-3-methoxyphenyl)methanol

HRID 2221507

反応式

HRID 2221507 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:7][CH:8]=[C:9]([CH2:11][O:12][C:13]2[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][C:14]=2[O:21][CH3:22])[N:10]=1.C(O)C.[BH4-].[Na+].O>O1CCCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[O:7][CH:8]=[C:9]([CH2:11][O:12][C:13]2[CH:20]=[CH:19][C:16]([CH2:17][OH:18])=[CH:15][C:14]=2[O:21][CH3:22])[N:10]=1

参加物

6

反応物 4

HCID 702EthanolHCID 962WaterHCID 4311764Sodium borohydrideHCID 866057054-{[2-(2-Furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxybenzaldehyde

生成物 1

HCID 69215267(4-([2-(2-Furyl)-1,3-oxazol-4-yl]methoxy)-3-methoxyphenyl)methanol収率 86%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-{[2-(2-furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxybenzaldehyde (9.70 g) in tetrahydrofuran (100 mL)-ethanol (50 mL) was gradually added sodium borohydride (1.23 g) at room temperature. After stirring at room temperature for 30 min., water was added to the reaction mixture and the precipitated crystals were collected by filtration to give (4-{[2-(2-furyl)-1,3-oxazol-4-yl]methoxy}-3-methoxyphenyl)methanol as pale-brown crystals (8.40 g, yield 86%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 117-118° C.

後処理

  1. customat room temperature
  2. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-01be4d968ba447338367c0917c83d519
出典データセット
uspto-grants-2008_05
特許番号
US07368578B2

関連ノート

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