3-benzyloxy-1-phenyl-1H-pyrazole-4-carbaldehyde → HCID 178519806、化合物
反応式
C([O:8][C:9]1[C:13]([CH:14]=[O:15])=[CH:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)C1C=CC=CC=1>[Pd].O1CCCC1>[OH:8][C:9]1[C:13]([CH:14]=[O:15])=[CH:12][N:11]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:10]=1参加物
4
実験手順
3-Benzyloxy-1-phenyl-1H-pyrazole-4-carbaldehyde (0.30 g), 5% palladium on carbon (0.50 g) and tetrahydrofuran (10 mL) were subjected to catalytic reduction under a hydrogen atmosphere and atmospheric pressure. The catalyst was filtered off and the filtrate was concentrated to give 3-hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde as colorless crystals (0.16 g, yield 76%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 196-197° C.
後処理
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d3db44bb8622490186fe83c4aeae9d7a
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07368578B2
反応ノート
読み込み中…