Water → 4-(4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazol-2-yl)morpholine

To a solution of diethyl {[5-methyl-2-(morpholin-4-yl)-1,3-thiazol-4-yl]methyl}phosphonate (1.56 g) in tetrahydrofuran (50 mL) was added sodium hydride (60% in oil, 0.22 g) at room temperature, and the mixture was stirred for 30 min. 3-(Methoxymethoxy)-1-phenyl-1H-pyrazole-4-carbaldehyde (1.14 g) was added to the reaction mixture, and the mixture was heated under reflux for 1.5 hrs. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography and eluted with acetone-hexane (1:5, v/v) to give 4-(4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazol-2-yl)morpholine as pale-yellow crystals (1.05 g, yield 54%). melting point: 162-164° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1.5 hrs
3. extractionthe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was washed with saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated
7. washeluted with acetone-hexane (1:5

ORDレコード

ord-05a277754d8c4cbca63e2edd7821b342

出典データセット

uspto-grants-2008_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07368578B2