Water → 2-[4'-(3''-Hydroxypropoxy)phenyl]-6-iodoimidazo[1,2-a]pyridine

HRID 222229ノート

反応式

HRID 222229 の反応式
[O:1]([CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]=[C:21]3[CH:26]=[CH:25][C:24]([I:27])=[CH:23][N:22]3[CH:28]=2)=[CH:15][CH:14]=1)[Si](C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Cl-].[NH4+].O>O1CCCC1.C(#N)C>[OH:1][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[N:20]=[C:21]3[CH:26]=[CH:25][C:24]([I:27])=[CH:23][N:22]3[CH:28]=2)=[CH:17][CH:18]=1

参加物

7

反応物 4

HCID 962WaterHCID 25517Ammonium ChlorideHCID 2724141Tetrabutylammonium FluorideHCID 671360922-[4'-(3''-t-Butyldimethylsiloxypropoxy)phenyl]-6-iodoimidazo[1,2-a]pyridine

生成物 1

HCID 247571022-[4'-(3''-Hydroxypropoxy)phenyl]-6-iodoimidazo[1,2-a]pyridine収率 87.3%

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

1.52 g (corresponding to 2.99 mmol) of 2-[4′-(3″-t-butyldimethylsiloxypropoxy)phenyl]-6-iodoimidazo[1,2-a]pyridine was dissolved in 5.0 mL of tetrahydrofuran, and 2.99 mL of a 1.0 mol/L tetrahydrofuran solution of tetrabutylammoniumfluoride was added thereto. After the reaction mixture was stirred at room temperature for 30 minutes, ammonium chloride solution was added followed by the addition of 10 mL of water and 5.0 mL of acetonitrile to filter precipitates. The filtered precipitates were washed with water and acetonitrile in this order, to obtain 1.03 g (corresponding to 2.61 mmol) of 2-[4′-(3″-hydroxypropoxy)phenyl]-6-iodoimidazo[1,2-a]pyridine (FIG. 10, Step 5).

後処理

  1. filtrationto filter
  2. customprecipitates
  3. customThe filtered precipitates
  4. washwere washed with water and acetonitrile in this order

出典と根拠

ORDレコード
ord-82c5339c8ea94735b4965065c489ca69
出典データセット
uspto-grants-2012_06
特許番号
US08207189B2

反応ノート

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