Trifluoroacetic acid → 2-(4-Benzylpiperidin-1-yl)ethan-1-amine

HRID 2223711

反応式

HRID 2223711 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[CH2:16]([CH:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][NH2:7])[CH2:15][CH2:14]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59715914[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 27798312-(4-Benzylpiperidin-1-yl)ethan-1-amine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (1.34 g, 4.2 mmol) is dissolved in CHCl3 (3 mL) and treated with TFA (3 mL) for 2 h at 20° C. The solvent is evaporated, the residue dissolved CH2Cl2 (100 mL) and washed with 1M aqueous NaOH (2×30 mL). The organic layer is dried (Na2SO4), filtered and concentrated to provide the title compound.

後処理

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved CH2Cl2 (100 mL)
  3. washwashed with 1M aqueous NaOH (2×30 mL)
  4. dry with materialThe organic layer is dried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-613c097532794b6eb35e701bbccad6b1
出典データセット
uspto-grants-2008_05
特許番号
US07375227B2

関連ノート

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