Hydrochloric Acid → 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetic acid

HRID 2225209ノート

反応式

HRID 2225209 の反応式
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[NH:12][CH2:13][C:14]([O:16]CC)=[O:15].[Li+].[OH-].CO.Cl>C1COCC1>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[NH:12][CH2:13][C:14]([OH:16])=[O:15]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 68469013ethyl 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetate

生成物 1

HCID 219911872-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Preparation I6, Step 3: A sample of ethyl 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetate (75 mg) was dissolved in THF (6 mL). The resulting solution was charged successively with an aqueous solution of LiOH (12.5 mg in 2 mL water) and methanol (2 mL). The reaction mixture was stirred for 2 h before being acidified with 1N HCl and extracted with EtOAc. The organic extracts were combined, washed with water and brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure to afford 2-(5-(trifluoromethyl)-1H-indazol-3-ylamino)acetic acid. MS found: (M+H)+=260.22.

後処理

  1. customPreparation I6, Step 3
  2. extractionextracted with EtOAc
  3. washwashed with water and brine
  4. dry with materialdried (sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5b28191dd484457ca1b791e613ed416a
出典データセット
uspto-grants-2008_05
特許番号
US07378409B2

反応ノート

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