Trifluoroacetic acid → HCID 18655204、化合物

HRID 2226589ノート

反応式

HRID 2226589 の反応式
C1(C[O:8][C:9](=[O:43])[C@@H:10]([NH:19][C@@H:20]([CH3:42])[C:21](=[O:41])[O:22][C@@H:23]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:24](=[O:33])[O:25]CC2C=CC=CC=2)[CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)C=CC=CC=1.FC(F)(F)C(O)=O>C(OCC)(=O)C.[Pd]>[C:24]([C@@H:23]([O:22][C:21](=[O:41])[C@@H:20]([NH:19][C@@H:10]([CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9]([OH:43])=[O:8])[CH3:42])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)([OH:33])=[O:25]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 54415138HCID 54415138、化合物

生成物 1

HCID 18655204HCID 18655204、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

The product of step b) (0.5 g) in ethyl acetate (30 ml) and trifluoroacetic acid (2 ml) was hydrogenated at 1 bar over 10% palladium on charcoal for 1 day. The catalyst was filtered off, the solvent evaporated and the residue purified by reverse phase HPLC with water/methanol mixtures as eluant, to give the title acid (0.14 g), mp 199°-200°.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated
  3. customthe residue purified by reverse phase HPLC with water/methanol
  4. customto give the title acid (0.14 g), mp 199°-200°

出典と根拠

ORDレコード
ord-c0c71871d5f3424199e67e15a273845e
出典データセット
uspto-grants-1994_09
特許番号
US05348978

反応ノート

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