Acrylonitrile → Piperidine-1-propylamine

HRID 2226620ノート

反応式

HRID 2226620 の反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7](#[N:10])[CH:8]=[CH2:9].N1(C(C)C#N)CCCCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(O)C.O1CCCC1>[NH2:10][CH2:7][CH2:8][CH2:9][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

7

反応物 4

HCID 7855AcrylonitrileHCID 8082PiperidineHCID 129574652-(Piperidin-1-yl)propanenitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 19049Piperidine-1-propylamine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Reaction of piperidine (Aldrich, 8.4 g, 100 mmol) with acrylonitrile (7.96 g, 150 mmol) in ethanol (25 mL), reduction of the resulting piperidinopropionitrile with lithium aluminum hydride (5 g, 125 mmol) in tetrahydrofuran (150 mL), work-up and distillation under reduced pressure as described for Example 3 gave the title compound. Yield: 3 g (21%); bp. 65°-66° (6 Torr); [lit. bp. 110°-115° C. (31 Torr), J. Corse et al., J. Amer. Chem. Soc., 68, 1911 (1946)].

後処理

  1. distillationdistillation under reduced pressure

出典と根拠

ORDレコード
ord-f036c09dfb994ae8973e66bcfb8ebc39
出典データセット
uspto-grants-1994_09
特許番号
US05349063

反応ノート

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