Azobisisobutyronitrile → Methyl 3-bromomethyl-5-phenylbenzoate

HRID 2228020ノート

反応式

HRID 2228020 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[Br:18]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>>[Br:18][CH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

参加物

5

反応物 4

HCID 6547AzobisisobutyronitrileHCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 11379139Methyl 3-methyl-5-phenylbenzoate

生成物 1

HCID 18474535Methyl 3-bromomethyl-5-phenylbenzoate収率 80%

実験手順

A solution of methyl 3-methyl-5-phenylbenzoate (3.5 g; 15.6 mmol); N-bromosuccinimide (2.78 g; 15.6 mmol), 2,2′-azobis(2′-methylpropionitrile) (0.12 g; 0.72 mmol) and benzoylperoxide (0.12 g; 0.48 mmol) in tetrachloroamethane (120 ml) was heated at reflux for 5 hours. After evaporation to dryness, the residue was purified by flash chromatography eluting with petroleum ether/ethyl acetate (97/3) to give methyl 3-bromomethyl-5-phenylbenzoate as a solid. Yield=80%.

後処理

  1. temperatureat reflux for 5 hours
  2. customAfter evaporation to dryness
  3. customthe residue was purified by flash chromatography
  4. washeluting with petroleum ether/ethyl acetate (97/3)

出典と根拠

ORDレコード
ord-99d62e40e6e74a66bba371b6ed068a51
出典データセット
uspto-grants-2002_07
特許番号
US06414145B1

反応ノート

読み込み中…