Ethanol → 2-chloro-6-fluoro-N'-hydroxybenzenecarboximidamide
反応式
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].Cl.[NH2:12][OH:13].C(=O)([O-])[O-].[Na+].[Na+].C(O)C>O>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4](=[N:12][OH:13])[NH2:5]参加物
6
反応条件
- 温度
- 72.5 °C
実験手順
A mixture of 15.6 g of 2-chloro-6-fluorobenzonitrile, 9.0 g of hydroxylamine hydrochloride, 7.4 g of sodium carbonate, 50 ml of ethanol and 15 ml of water was stirred at 70-75° C. for 16 h. The solvent was evaporated and the residue was stirred with tertbutyl methyl ether, and the filtrate afforded, after evaporation of the solvent, 17.6 g of the desired product of m.p. 115-120° C.
後処理
- customThe solvent was evaporated
- stirringthe residue was stirred with tertbutyl methyl ether
- customthe filtrate afforded
- customafter evaporation of the solvent, 17.6 g of the desired product of m.p. 115-120° C.
出典と根拠
- ORDレコード
- ord-5be28282c74240769217d730973e239e
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06417398B1
反応ノート
読み込み中…