Sodium Hydroxide → HCID 53776389、化合物

HRID 22298ノート

反応式

HRID 22298 の反応式
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:9]=[CH:10][CH:11]=1)[O:5][CH2:6][C:7]#[N:8].Cl.[NH2:14][OH:15].[OH-].[Na+]>C(O)C.O>[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:9]=[CH:10][CH:11]=1)[O:5][CH2:6][C:7](=[N:14][OH:15])[NH2:8]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 22075474HCID 22075474、化合物

生成物 1

HCID 53776389HCID 53776389、化合物収率 90.2%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

29.2 g (160.7 mmol) of 3-chloro-2-methyl-phenoxyacetonitrile are added to a solution of 13.5 g (194.2 mmol) of hydroxylamine hydrochloride, 7.7 g (194.2 mmol) of sodium hydroxide in 265 ml of ethanol and 68 ml of water. The mixture is heated at reflux temperature until the reaction is complete (approximately 48 to 60 hours) and the entire batch is subsequently stirred into 250 ml of water. The solid which precipitates in this process is separated off, washed with a small amount of water and dried. 31.1 g (90.2% of theory) of 3-chloro-2-methylphenoxyacetamide oxime are obtained.

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux temperature until the reaction
  3. custom(approximately 48 to 60 hours)
  4. customThe solid which precipitates in this process
  5. customis separated off
  6. washwashed with a small amount of water
  7. customdried

出典と根拠

ORDレコード
ord-aa0f88f5567d4fcda3a90af48f11be4b
出典データセット
uspto-grants-1995_06
特許番号
US05428047

反応ノート

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