Sodium borohydride → Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

HRID 2230265ノート

反応式

HRID 2230265 の反応式
[BH4-].[Na+].[CH2:3]([O:5][C:6](=[O:20])[CH:7]=[C:8]1[C:18]2=[C:19]3[C:14](=[CH:15][CH:16]=[CH:17]2)[CH:13]=[CH:12][CH:11]=[C:10]3[CH2:9]1)[CH3:4]>CO.Cl[Pd]Cl>[CH2:3]([O:5][C:6](=[O:20])[CH2:7][CH:8]1[C:18]2=[C:19]3[C:14](=[CH:15][CH:16]=[CH:17]2)[CH:13]=[CH:12][CH:11]=[C:10]3[CH2:9]1)[CH3:4]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 70179131Ethyl2-(1,2-dihydro-1-acenaphthylenylidene)acetate

生成物 1

HCID 13715672Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

試薬・触媒・溶媒 2

HCID 24290Palladium Chloride触媒HCID 887Methanol溶媒2 回

実験手順

55 mg of PdCl2 in 5 ml of methanol are treated with 25 mg of sodium borohydride. After 15 minutes' stirring, the compound obtained in Step B (1 g, 4.20.10−3 mol), diluted with methanol (25 ml), is added. The mixture is purged with argon and placed under a hydrogen atmosphere. After 2 hours 30 minutes' hydrogenation, the reaction mixture is filtered over Celite, rinsed and then evaporated under reduced pressure.

後処理

  1. additionis added
  2. customThe mixture is purged with argon
  3. waitAfter 2 hours 30 minutes' hydrogenation
  4. filtrationthe reaction mixture is filtered over Celite
  5. washrinsed
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-455c973d4abd4c9dbc62bc0345c0c13c
出典データセット
uspto-grants-2002_07
特許番号
US06423870B1

反応ノート

読み込み中…