Sodium hydride → HCID 588994、化合物
反応式
Cl[CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=[CH:5]1.[H-].[Na+]>O1CCCC1>[CH:3]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=[CH:5]1)=[CH2:2]参加物
4
実験手順
To 3.61 g (20 mmoles) of 1-(2-chloroethyl)benzimidazole in 50 ml of tetrahydrofuran was added in portions 960 mg (20 mmoles) of 50% sodium hydride and the mixture allowed to stir for 3 hours. The solids were filtered, washed with tetrahydrofuran and the washings and filtrate evaporated to dryness. The residue was dissolved in acetonitrile, washed with hexane and the acetonitrile concentrated to give 2.77 g of product as a yellow oil.
後処理
- filtrationThe solids were filtered
- washwashed with tetrahydrofuran
- customthe washings and filtrate evaporated to dryness
- dissolutionThe residue was dissolved in acetonitrile
- washwashed with hexane
- concentrationthe acetonitrile concentrated
出典と根拠
- ORDレコード
- ord-0c66a79fb5424b068d81e7f5fa123f41
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04782050
反応ノート
読み込み中…