Water → 2-(1-methoxyethyl)-1H-1,3-benzodiazole
反応式
[OH:1][CH:2]([C:4]1[NH:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[N:8]=1)[CH3:3].[H-].[Na+].[CH3:15]I.O>CN(C)C=O>[CH3:15][O:1][CH:2]([C:4]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[N:5]=1)[CH3:3]参加物
6
実験手順
To a solution of 4.05 g of 1-hydroxyethylbenzimidazole in 25 ml of dimethylformamide was added 1.2 g of 50% sodium hydride in oil, and the mixture stirred for 30 minutes. Methyl iodide (3.55 g) was added and the reaction mixture stirred at room temperature overnight. Water (200 ml) was added and the product extracted with ethyl acetate. The extracts were combined, dried and concentrated to an oil which was chromatographed on 130 g of silica gel using 5% methanol in chloroform as the eluent to give 2.36 g of brown oil.
後処理
- stirringthe reaction mixture stirred at room temperature overnight
- extractionthe product extracted with ethyl acetate
- customdried
- concentrationconcentrated to an oil which
- customwas chromatographed on 130 g of silica gel using 5% methanol in chloroform as the eluent
出典と根拠
- ORDレコード
- ord-303ea52e2aa3477f87138105d0de21f7
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04782050
反応ノート
読み込み中…