Acetyl chloride → 1-Acetyl-4-phenylimidazole

HRID 2231253ノート

反応式

HRID 2231253 の反応式
[C:1]1([C:7]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[C:14](Cl)(=[O:16])[CH3:15]>O1CCCC1>[C:14]([N:10]1[CH:11]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=[CH:9]1)(=[O:16])[CH3:15]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 24758Sodium hydrideHCID 178418822HCID 178418822、化合物

生成物 1

HCID 108214021-Acetyl-4-phenylimidazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-phenylimidazole in 40 ml of tetrahydrofuran was added portionwise 1.66 g of 50% sodium hydride. After stirring for 20 minutes, 2.46 ml of acetyl chloride was added over 10 minutes and the reaction mixture allowed to stir overnight at room temperature. The reaction was filtered and the filtrate concentrated to give 4 g of crude product which was purified by chromatographing on 150 g of silica gel using 5% methanol in chloroform as eluent, 2.88 g.

後処理

  1. stirringto stir overnight at room temperature
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-912abe7593c647b99ca32f4469d7bc09
出典データセット
uspto-grants-1988_11
特許番号
US04782050

反応ノート

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