Water → 1-Methyl-5-phenyl-1H-imidazole

HRID 2231254ノート

反応式

HRID 2231254 の反応式
C([N:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:6]=[CH:5]1)(=O)C.[CH3:15]I.O>C(#N)C>[CH3:15][N:6]1[C:7]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:8][N:4]=[CH:5]1

参加物

5

反応物 3

HCID 962WaterHCID 6328Methyl iodideHCID 108214021-Acetyl-4-phenylimidazole

生成物 1

HCID 37463431-Methyl-5-phenyl-1H-imidazole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To 2.88 g of 1-acetyl-4-phenylimidazole in 50 ml of acetonitrile was added 5.8 ml of methyl iodide and the reaction mixture sealed in a flask over a weekend. The reaction mixture was poured into water and then decanted from insoluble oil. The pH of the decanted solution was adjusted to 9 with sodium carbonate and the solution extracted with chloroform. The extracts were combined, dried over magnesium sulfate and concentrated to give 1.02 g of crude product which was chromatographed on 50 g of silica gel using 30% ethyl acetate in chloroform as the eluent, 640 mg.

後処理

  1. customthe reaction mixture sealed in a flask over a weekend
  2. customdecanted from insoluble oil
  3. extractionthe solution extracted with chloroform
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-13d75eb2c2994c5dbcb6047becab4022
出典データセット
uspto-grants-1988_11
特許番号
US04782050

反応ノート

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